"Die-off" symptoms can begin almost immediately after starting the supplement. It can hit different people in different ways. Reactions include extreme fatigue, diarrhea, headaches, muscle/joint achiness or flu-like symptoms. Severity differs also from person to person, depending on the extent of infection.

Keep in mind that such symptoms are positive signs. Nevertheless, they can be unpleasant. Some people may not want to continue because of the discomfort. Others handle it better. Others experience no such effect.

Hereís what to do in case of substantial detoxification symptoms,:
  • Reduce the number of tablets, or even stop them altogether for a while.

  • You may need a day or two, or even a week, to allow your body to process the "die-off."

  • When you feel better, you can resume the supplement at a low dose and increase slowly.

  • Holistic practitioners can usually provide a supportive detoxification program for individuals who experience a strong "die-off" response. In my clinic, this program includes taking vitamin C to bowel tolerance. Such a regimen is best done under professional guidance.

Other than the "die-off" detoxification effect among some individuals, olive leaf extract appears to create no side effects. Past research with calcium elenolate, the derivative or oleuropein, included safety studies with laboratory animals. They were dosed orally and also via injection. The only symptom observed was a mild irritation of the mucous membrane among some animals at the injection site. Since olive leaf extract is taken orally, this observation is basically irrelevant.

The research indicated that doses many times higher than recommended are unlikely to produce toxic or other adverse side effects. During 1993 testing of the liquid form of the product against the herpes virus, there were no observed or reported side effects.

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